Ontology highlight
ABSTRACT:
SUBMITTER: Steichen JM
PROVIDER: S-EPMC11309785 | biostudies-literature | 2024 May
REPOSITORIES: biostudies-literature
Steichen Jon M JM Phung Ivy I Salcedo Eugenia E Ozorowski Gabriel G Willis Jordan R JR Baboo Sabyasachi S Liguori Alessia A Cottrell Christopher A CA Torres Jonathan L JL Madden Patrick J PJ Ma Krystal M KM Sutton Henry J HJ Lee Jeong Hyun JH Kalyuzhniy Oleksandr O Allen Joel D JD Rodriguez Oscar L OL Adachi Yumiko Y Mullen Tina-Marie TM Georgeson Erik E Kubitz Michael M Burns Alison A Barman Shawn S Mopuri Rohini R Metz Amanda A Altheide Tasha K TK Diedrich Jolene K JK Saha Swati S Shields Kaitlyn K Schultze Steven E SE Smith Melissa L ML Schiffner Torben T Burton Dennis R DR Watson Corey T CT Bosinger Steven E SE Crispin Max M Yates John R JR Paulson James C JC Ward Andrew B AB Sok Devin D Crotty Shane S Schief William R WR
Science (New York, N.Y.) 20240517 6697
Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen recognition is typically dominated by heavy chain complementarity determining region 3 (HCDR3) interactions, and vaccine priming of HCDR3-dominant bnAbs by germline-targeting immunogens has not been demonstrated in humans or outbred animals. In this work, immunization with N332-GT5, an HIV envelope trimer designed to target precu ...[more]