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Expression of the aac(6')-Ib-cr Gene in Class 1 Integrons.

ABSTRACT: aac(6')-Ib-cr is a plasmid-mediated quinolone resistance gene embedded within a gene cassette, most often within an integron. It confers resistance to quinolones and aminoglycosides. We investigated the role of a 101-bp fragment frequently present upstream of the aac(6')-Ib-cr gene cassette and found that it contributes to the expression of aac(6')-Ib-cr and provides an alternative start codon, confirming the length of the AAC(6')-Ib-cr protein to 199 amino acids.

SUBMITTER: Raherison S

PROVIDER: S-EPMC5404527 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Expression of the aac(6')-Ib-cr Gene in Class 1 Integrons.

Raherison Sophie S Jove Thomas T Gaschet Margaux M Pinault Emilie E Tabesse Aurore A Torres Carmen C Ploy Marie-Cécile MC

Antimicrobial agents and chemotherapy 20170424 5

aac(6')-Ib-cr is a plasmid-mediated quinolone resistance gene embedded within a gene cassette, most often within an integron. It confers resistance to quinolones and aminoglycosides. We investigated the role of a 101-bp fragment frequently present upstream of the aac(6')-Ib-cr gene cassette and found that it contributes to the expression of aac(6')-Ib-cr and provides an alternative start codon, confirming the length of the AAC(6')-Ib-cr protein to 199 amino acids. ...[more]

PMID: 28223390

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