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QnrE1, a Member of a New Family of Plasmid-Located Quinolone Resistance Genes, Originated from the Chromosome of Enterobacter Species.

ABSTRACT: qnrE1, found in a clinical Klebsiella pneumoniae isolate, was undetectable by PCR assays used for the six qnr families. qnrE1 was located on a conjugative plasmid (ca. 185 kb) and differed from qnrB alleles by 25%. Phylogenetic reconstructions of qnr genes and proteins and analysis of the qnrE1 surroundings showed that this gene belongs to a new qnr family and was likely mobilized by ISEcp1 from the chromosome of Enterobacter spp. to plasmids of K. pneumoniae.

SUBMITTER: Albornoz E 

PROVIDER: S-EPMC5404601 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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<i>qnrE1</i>, a Member of a New Family of Plasmid-Located Quinolone Resistance Genes, Originated from the Chromosome of Enterobacter Species.

Albornoz Ezequiel E   Tijet Nathalie N   De Belder Denise D   Gomez Sonia S   Martino Florencia F   Corso Alejandra A   Melano Roberto G RG   Petroni Alejandro A  

Antimicrobial agents and chemotherapy 20170424 5

<i>qnrE1</i>, found in a clinical <i>Klebsiella pneumoniae</i> isolate, was undetectable by PCR assays used for the six <i>qnr</i> families. <i>qnrE1</i> was located on a conjugative plasmid (ca. 185 kb) and differed from <i>qnrB</i> alleles by 25%. Phylogenetic reconstructions of <i>qnr</i> genes and proteins and analysis of the <i>qnrE1</i> surroundings showed that this gene belongs to a new <i>qnr</i> family and was likely mobilized by IS<i>Ecp1</i> from the chromosome of <i>Enterobacter</i>  ...[more]

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