Dataset Information
Undervaccination with diphtheria, tetanus, and pertussis vaccine: National trends and association with pertussis risk in young children.
Ontology highlight
ABSTRACT: Background
The high coverage for ?3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study.Methods
In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression.Results
The prevalence of undervaccination was 60.6% (median 16 days) and decreasing (p < 0.0001). Among 145 cases and 2,900 controls, 58 (40.0%) and 721 (24.9%) were undervaccinated (OR 2.28, 95% CI 1.57-3.31). The attributable risk percent was 22.5% (95% CI 14.5-27.9).Conclusions
Undervaccination was decreasing. Approximately up to one-fifth pertussis cases in children aged 3-35 months could have been prevented with on-time vaccination.
SUBMITTER: Huang WT
PROVIDER: S-EPMC5404624 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Undervaccination with diphtheria, tetanus, and pertussis vaccine: National trends and association with pertussis risk in young children.
Human vaccines & immunotherapeutics 20161118 4
<h4>Background</h4>The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study.<h4>Methods</h4>In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with ...[more]
