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Synthesis of ribavirin 2'-Me-C-nucleoside analogues.


ABSTRACT: An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2'-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.

SUBMITTER: Cosson F 

PROVIDER: S-EPMC5405694 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Synthesis of ribavirin 2'-Me-<i>C</i>-nucleoside analogues.

Cosson Fanny F   Faroux Aline A   Baltaze Jean-Pierre JP   Farjon Jonathan J   Guillot Régis R   Uziel Jacques J   Lubin-Germain Nadège N  

Beilstein journal of organic chemistry 20170421


An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2'-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization. ...[more]

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