Ontology highlight
ABSTRACT:
SUBMITTER: Stern WM
PROVIDER: S-EPMC5405762 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Stern William M WM Sander Josemir W JW Rothwell John C JC Sisodiya Sanjay M SM
Neurology 20170329 17
<h4>Objective</h4>Dravet syndrome is a rare neurodevelopmental disorder characterized by seizures and other neurologic problems. <i>SCN1A</i> mutations account for ∼80% of cases. Animal studies have implicated mutation-related dysregulated cortical inhibitory networks in its pathophysiology. We investigated such networks in people with the condition.<h4>Methods</h4>Transcranial magnetic stimulation using single and paired pulse paradigms was applied to people with Dravet syndrome and to 2 contro ...[more]