Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation.
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ABSTRACT:
SUBMITTER: Wei HS
PROVIDER: S-EPMC5405863 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation.
Wei Helen Shinru HS Kang Hongyi H Rasheed Izad-Yar Daniel ID Zhou Sitong S Lou Nanhong N Gershteyn Anna A McConnell Evan Daniel ED Wang Yixuan Y Richardson Kristopher Emil KE Palmer Andre Francis AF Xu Chris C Wan Jiandi J Nedergaard Maiken M
Neuron 20160804 4
Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. In vivo analyses showed ...[more]
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