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Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal.

ABSTRACT: A simple and selective assay for detecting methylglyoxal (MGO), a metabolite associated with diabetes, was developed by combining a bio-inspired chemical reaction with the anti-aggregation of gold nanoparticles. This assay could detect MGO at as low as 1 ?M by the naked eye and 0.05 ?M by UV/vis spectrometry, within the clinical range marking oxidative stress in diabetes, and demonstrated high selectivity over other physiologically relevant ketones and aldehydes.

SUBMITTER: Wang ST

PROVIDER: S-EPMC5408930 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal.

Wang Shih-Ting ST Lin Yiyang Y Lin Yiyang Y Spicer Christopher D CD Stevens Molly M MM

Chemical communications (Cambridge, England) 20150701 55

A simple and selective assay for detecting methylglyoxal (MGO), a metabolite associated with diabetes, was developed by combining a bio-inspired chemical reaction with the anti-aggregation of gold nanoparticles. This assay could detect MGO at as low as 1 μM by the naked eye and 0.05 μM by UV/vis spectrometry, within the clinical range marking oxidative stress in diabetes, and demonstrated high selectivity over other physiologically relevant ketones and aldehydes. ...[more]

PMID: 26073427

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