Ontology highlight
ABSTRACT:
SUBMITTER: Guan H
PROVIDER: S-EPMC5409451 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Guan Hongxin H Tian Juan J Qin Bo B Wojdyla Justyna Aleksandra JA Wang Bei B Zhao Zhendong Z Wang Meitian M Cui Sheng S
Science advances 20170428 4
Enterovirus 71 (EV71) is the major pathogen responsible for outbreaks of hand, foot, and mouth disease. EV71 nonstructural protein 2C participates in many critical events throughout the virus life cycle; however, its precise role is not fully understood. Lack of a high-resolution structure made it difficult to elucidate 2C activity and prevented inhibitor development. We report the 2.5 Å-resolution crystal structure of the soluble part of EV71 2C, containing an adenosine triphosphatase (ATPase) ...[more]