Ontology highlight
ABSTRACT:
SUBMITTER: Choi JH
PROVIDER: S-EPMC5410272 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Choi Ji-Hye JH Kim Min Jae MJ Park Yong Keun YK Im Jong-Yeop JY Kwon So Mee SM Kim Hyung Chul HC Woo Hyun Goo HG Wang Hee-Jung HJ
Oncotarget 20170401 14
Recurrence of hepatocellular carcinoma (HCC) even after curative resection causes dismal outcomes of patients. Here, to delineate the driver events of genomic and transcription alteration during HCC recurrence, we performed RNA-Seq profiling of the paired primary and recurrent tumors from two patients with intrahepatic HCC. By comparing the mutational and transcriptomic profiles, we identified somatic mutations acquired by HCC recurrence including novel mutants of GOLGB1 (E2721V) and SF3B3 (H804 ...[more]