Ontology highlight
ABSTRACT:
SUBMITTER: Koetz-Ploch L
PROVIDER: S-EPMC5411293 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Koetz-Ploch Lisa L Hanniford Douglas D Dolgalev Igor I Sokolova Elena E Zhong Judy J Díaz-Martínez Marta M Bernstein Emily E Darvishian Farbod F Flaherty Keith T KT Chapman Paul B PB Tawbi Hussein H Hernando Eva E
Pigment cell & melanoma research 20170419 3
Melanoma patients with BRAF<sup>V</sup><sup>600E</sup> -mutant tumors display striking responses to BRAF inhibitors (BRAFi); however, almost all invariably relapse with drug-resistant disease. Here, we report that microRNA-125a (miR-125a) expression is upregulated in human melanoma cells and patient tissues upon acquisition of BRAFi resistance. We show that miR-125a induction confers resistance to BRAF<sup>V</sup><sup>600E</sup> melanoma cells to BRAFi by directly suppressing pro-apoptotic compo ...[more]