Ontology highlight
ABSTRACT:
SUBMITTER: Wei X
PROVIDER: S-EPMC5412569 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wei Xiaofan X Wang Xiang X Zhan Jun J Chen Yuhan Y Fang Weigang W Zhang Lingqiang L Zhang Hongquan H
The Journal of cell biology 20170413 5
Integrin activation is an indispensable step for various integrin-mediated biological functions. Kindlin-2 is known to coactivate integrins with Talin; however, molecules that restrict integrin activation are elusive. Here, we demonstrate that the E3 ubiquitin ligase Smurf1 controls the amount of Kindlin-2 protein in cells and hinders integrin activation. Smurf1 interacts with and promotes Kindlin-2 ubiquitination and degradation. Smurf1 selectively mediates degradation of Kindlin-2 but not Tali ...[more]