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Evaluation of intravoxel incoherent motion fitting methods in low-perfused tissue.


ABSTRACT: To investigate the robustness of constrained and simultaneous intravoxel incoherent motion (IVIM) fitting methods and the estimated IVIM parameters (D, D* and f) for applications in brain and low-perfused tissues.Model data simulations relevant to brain and low-perfused tumor tissues were computed to assess the accuracy, relative bias, and reproducibility (CV%) of the fitting methods in estimating the IVIM parameters. The simulations were performed at a series of signal-to-noise ratio (SNR) levels to assess the influence of noise on the fitting.The estimated IVIM parameters from model simulations were found significantly different (P?

SUBMITTER: Meeus EM 

PROVIDER: S-EPMC5412931 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Evaluation of intravoxel incoherent motion fitting methods in low-perfused tissue.

Meeus Emma M EM   Novak Jan J   Withey Stephanie B SB   Zarinabad Niloufar N   Dehghani Hamid H   Peet Andrew C AC  

Journal of magnetic resonance imaging : JMRI 20160822 5


<h4>Purpose</h4>To investigate the robustness of constrained and simultaneous intravoxel incoherent motion (IVIM) fitting methods and the estimated IVIM parameters (D, D* and f) for applications in brain and low-perfused tissues.<h4>Materials and methods</h4>Model data simulations relevant to brain and low-perfused tumor tissues were computed to assess the accuracy, relative bias, and reproducibility (CV%) of the fitting methods in estimating the IVIM parameters. The simulations were performed a  ...[more]

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