Ontology highlight
ABSTRACT:
SUBMITTER: Sun D
PROVIDER: S-EPMC5413323 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20170417 5
Reactive remodeling of optic nerve head astrocytes is consistently observed in glaucoma and other optic nerve injuries. However, it is unknown whether this reactivity is beneficial or harmful for visual function. In this study, we used the Cre recombinase (Cre)-<i>loxP</i> system under regulation of the mouse glial fibrillary acidic protein promoter to knock out the transcription factor signal transducer and activator of transcription 3 (STAT3) from astrocytes and test the effect this has on rea ...[more]