Ontology highlight
ABSTRACT:
SUBMITTER: Sun D
PROVIDER: S-EPMC3762692 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Glia 20130507 8
Reactive astrocytes are typically studied in models that cause irreversible mechanical damage to axons, neuronal cell bodies, and glia. Here, we evaluated the response of astrocytes in the optic nerve head to a subtle injury induced by a brief, mild elevation of the intraocular pressure. Astrocytes demonstrated reactive remodeling that peaked at three days, showing hypertrophy, process retraction, and simplification of their shape. This was not accompanied by any significant changes in the gene ...[more]