Ontology highlight
ABSTRACT:
SUBMITTER: Ising C
PROVIDER: S-EPMC5413341 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Ising Christina C Gallardo Gilbert G Leyns Cheryl E G CEG Wong Connie H CH Jiang Hong H Stewart Floy F Koscal Lauren J LJ Roh Joseph J Robinson Grace O GO Remolina Serrano Javier J Holtzman David M DM
The Journal of experimental medicine 20170417 5
Tauopathies are characterized by the progressive accumulation of hyperphosphorylated, aggregated forms of tau. Our laboratory has previously demonstrated that passive immunization with an anti-tau antibody, HJ8.5, decreased accumulation of pathological tau in a human P301S tau-expressing transgenic (P301S-tg) mouse model of frontotemporal dementia/tauopathy. To investigate whether the F<sub>c</sub> domain of HJ8.5 is required for the therapeutic effect, we engineered single-chain variable fragme ...[more]