Ontology highlight
ABSTRACT:
SUBMITTER: Lasagna-Reeves CA
PROVIDER: S-EPMC5745060 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Lasagna-Reeves Cristian A CA de Haro Maria M Hao Shuang S Park Jeehye J Rousseaux Maxime W C MW Al-Ramahi Ismael I Jafar-Nejad Paymaan P Vilanova-Velez Luis L See Lauren L De Maio Antonia A Nitschke Larissa L Wu Zhenyu Z Troncoso Juan C JC Westbrook Thomas F TF Tang Jianrong J Botas Juan J Zoghbi Huda Y HY
Neuron 20161006 2
Many neurodegenerative proteinopathies share a common pathogenic mechanism: the abnormal accumulation of disease-related proteins. As growing evidence indicates that reducing the steady-state levels of disease-causing proteins mitigates neurodegeneration in animal models, we developed a strategy to screen for genes that decrease the levels of tau, whose accumulation contributes to the pathology of both Alzheimer disease (AD) and progressive supranuclear palsy (PSP). Integrating parallel cell-bas ...[more]