Dataset Information

Peak Jump Power Reflects the Degree of Ambulatory Ability in Patients with Mitochondrial and Other Rare Diseases.

ABSTRACT: Metabolic diseases that lead to neuromuscular, bone, and joint involvement can reduce ambulation and quality of life. Using jumping mechanography, we developed a novel assessment, peak jump power (PJP), and related this to ambulatory ability in patients either having a known or suspected underlying rare disease. From adults and children, we recruited 88 healthy controls and 115 patients (61 with mitochondrial disease and 54 with another diagnosis). Patients were categorized as having no complaints of weakness or ambulation (ambulatory competent; AC), weakness but able to ambulate without aids (ambulatory weakness; AW), or not able to ambulate without aids such as a walker, cane, or wheelchair (ambulatory assistance; AA). Subjects were asked to perform five successive jumps from a squat position. Instantaneous power (W; watts) was calculated and the highest result was divided by the body mass (kg) to calculate PJP (W/kg). Between healthy controls and AC patients, there was no difference in mean PJP (20.5?±?7.0 W/kg vs. 19.0?±?7.4 W/kg, p?=?0.601; mean?±?SD). Progressively lower results were found in patients with AW with a mean PJP of 11.7?±?5.1 W/kg (p?

SUBMITTER: Newell C

PROVIDER: S-EPMC5413456 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Peak Jump Power Reflects the Degree of Ambulatory Ability in Patients with Mitochondrial and Other Rare Diseases.

Newell Christopher C Ramage Barbara B Nettel-Aguirre Alberto A Robu Ion I Khan Aneal A

JIMD reports 20160913

Metabolic diseases that lead to neuromuscular, bone, and joint involvement can reduce ambulation and quality of life. Using jumping mechanography, we developed a novel assessment, peak jump power (PJP), and related this to ambulatory ability in patients either having a known or suspected underlying rare disease. From adults and children, we recruited 88 healthy controls and 115 patients (61 with mitochondrial disease and 54 with another diagnosis). Patients were categorized as having no complain ...[more]

PMID: 27620484

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Dataset Information

Peak Jump Power Reflects the Degree of Ambulatory Ability in Patients with Mitochondrial and Other Rare Diseases.

Publications

Peak Jump Power Reflects the Degree of Ambulatory Ability in Patients with Mitochondrial and Other Rare Diseases.

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