Quantifying the distribution of protein oligomerization degree reflects cellular information capacity.

ABSTRACT: The generation of information, energy and biomass in living cells involves integrated processes that optimally evolve into complex and robust cellular networks. Protein homo-oligomerization, which is correlated with cooperativity in biology, is one means of scaling the complexity of protein networks. It can play critical roles in determining the sensitivity of genetic regulatory circuits and metabolic pathways. Therefore, understanding the roles of oligomerization may lead to new approaches of probing biological functions. Here, we analyzed the frequency of protein oligomerization degree in the cell proteome of nine different organisms, and then, we asked whether there are design trade-offs between protein oligomerization, information precision and energy costs of protein synthesis. Our re

SUBMITTER: Danielli L 

PROVIDER: S-EPMC7573690 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature