Ontology highlight
ABSTRACT:
SUBMITTER: Lee Y
PROVIDER: S-EPMC5414040 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Lee Yeunkum Y Lee Ji Soo JS Lee Kea Joo KJ Turner R Scott RS Hoe Hyang-Sook HS Pak Daniel T S DTS
Neuropharmacology 20170301
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces amyloid β (Aβ), the major component of hallmark AD plaques. Synaptic activity stimulates APP cleavage, whereas APP promotes excitatory synaptic transmission, suggesting APP participates in neuronal homeostasis. However, mechanisms linking synaptic activity to APP processing are unclear. Here we show that Polo-like kinase 2 (Plk2), an activity-indu ...[more]