Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection.
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ABSTRACT:
SUBMITTER: Winer BY
PROVIDER: S-EPMC5414730 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection.
Winer Benjamin Y BY Huang Tiffany T Low Benjamin E BE Avery Cindy C Pais Mihai-Alexandru MA Hrebikova Gabriela G Siu Evelyn E Chiriboga Luis L Wiles Michael V MV Ploss Alexander A
Virology 20161219
There are ~350 million chronic carriers of hepatitis B (HBV). While a prophylactic vaccine and drug regimens to suppress viremia are available, chronic HBV infection is rarely cured. HBV's limited host tropism leads to a scarcity of susceptible small animal models and is a hurdle to developing curative therapies. Mice that support engraftment with human hepatoctyes have traditionally been generated through crosses of murine liver injury models to immunodeficient backgrounds. Here, we describe th ...[more]
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