Ontology highlight
ABSTRACT:
SUBMITTER: Klein BJ
PROVIDER: S-EPMC5415407 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Klein Brianna J BJ Simithy Johayra J Wang Xiaolu X Ahn JaeWoo J Andrews Forest H FH Zhang Yi Y Côté Jacques J Shi Xiaobing X Garcia Benjamin A BA Kutateladze Tatiana G TG
Structure (London, England : 1993) 20170309 4
The monocytic leukemia zinc-finger protein-related factor (MORF) is a transcriptional coactivator and a catalytic subunit of the lysine acetyltransferase complex implicated in cancer and developmental diseases. We have previously shown that the double plant homeodomain finger (DPF) of MORF is capable of binding to acetylated histone H3. Here we demonstrate that the DPF of MORF recognizes many newly identified acylation marks. The mass spectrometry study provides comprehensive analysis of H3K14 a ...[more]