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Structural Elements Regulating AAA+ Protein Quality Control Machines.

ABSTRACT: Members of the ATPases Associated with various cellular Activities (AAA+) superfamily participate in essential and diverse cellular pathways in all kingdoms of life by harnessing the energy of ATP binding and hydrolysis to drive their biological functions. Although most AAA+ proteins share a ring-shaped architecture, AAA+ proteins have evolved distinct structural elements that are fine-tuned to their specific functions. A central question in the field is how ATP binding and hydrolysis are coupled to substrate translocation through the central channel of ring-forming AAA+ proteins. In this mini-review, we will discuss structural elements present in AAA+ proteins involved in protein quality control, drawing similarities to their known role in substrate interaction by AAA+ proteins involved in DNA translocation. Elements to be discussed include the pore loop-1, the Inter-Subunit Signaling (ISS) motif, and the Pre-Sensor I insert (PS-I) motif. Lastly, we will summarize our current understanding on the inter-relationship of those structural elements and propose a model how ATP binding and hydrolysis might be coupled to polypeptide translocation in protein quality control machines.

SUBMITTER: Chang CW

PROVIDER: S-EPMC5415569 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Structural Elements Regulating AAA+ Protein Quality Control Machines.

Chang Chiung-Wen CW Lee Sukyeong S Tsai Francis T F FTF

Frontiers in molecular biosciences 20170504

Members of the ATPases Associated with various cellular Activities (AAA+) superfamily participate in essential and diverse cellular pathways in all kingdoms of life by harnessing the energy of ATP binding and hydrolysis to drive their biological functions. Although most AAA+ proteins share a ring-shaped architecture, AAA+ proteins have evolved distinct structural elements that are fine-tuned to their specific functions. A central question in the field is how ATP binding and hydrolysis are couple ...[more]

PMID: 28523272

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Dataset Information

Structural Elements Regulating AAA+ Protein Quality Control Machines.

Publications

Structural Elements Regulating AAA+ Protein Quality Control Machines.

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