Ontology highlight
ABSTRACT:
SUBMITTER: Began J
PROVIDER: S-EPMC7231995 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Began Jakub J Cordier Baptiste B Březinová Jana J Delisle Jordan J Hexnerová Rozálie R Srb Pavel P Rampírová Petra P Kožíšek Milan M Baudet Mathieu M Couté Yohann Y Galinier Anne A Veverka Václav V Doan Thierry T Strisovsky Kvido K
The EMBO journal 20200113 10
Magnesium homeostasis is essential for life and depends on magnesium transporters, whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom, but their functions are largely elusive. Using proteomics, we find that Bacillus subtilis rhomboid protease YqgP interacts with the membrane-bound ATP-dependent processive metalloprotease FtsH and cleaves MgtE, the major high-affinity magnesium transporter in B. subtilis. MgtE cleavag ...[more]