Ontology highlight
ABSTRACT:
SUBMITTER: Rad-Malekshahi M
PROVIDER: S-EPMC5415879 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Rad-Malekshahi Mazda M Fransen Marieke F MF Krawczyk Małgorzata M Mansourian Mercedeh M Bourajjaj Meriem M Chen Jian J Ossendorp Ferry F Hennink Wim E WE Mastrobattista Enrico E Amidi Maryam M
Molecular pharmaceutics 20170127 5
The aim of the present study was to improve the immunogenicity of peptide epitope vaccines using novel nanocarriers based on self-assembling materials. Several studies demonstrated that peptide antigens in nanoparticulate form induce stronger immune responses than their soluble forms. However, several issues such as poor loading and risk of inducing T cell anergy due to premature release of antigenic epitopes have challenged the clinical success of such systems. In the present study, we develope ...[more]