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Stiff-Person Syndrome and Graves' Disease: A Pediatric Case Report.

ABSTRACT: A 9-year-old female child presented with a history of falls, weight loss, diffuse leg pain, and progressive gait disorder, following 1 previous event described as a tonic-clonic seizure. She had increased thyroid volume, brisk symmetric reflexes, abnormal gait, and painful spasms of the paraspinal musculature. Thyroid function tests indicated biochemical hyperthyroidism, and thyrotropin receptor antibodies were positive. Her electromyography showed continuous activation of normal motor units of the paraspinal and proximal lower extremity muscles. The patient had a diagnosis of Graves' disease with associated stiff-person syndrome, with elevated anti-glutamic acid decarboxylase antibody levels. After intravenous immunoglobulin therapy, her ambulation was substantially improved and the symptoms of stiff-person syndrome decreased dramatically.

SUBMITTER: Medeiros LM

PROVIDER: S-EPMC5417285 | biostudies-literature | 2016 Jan-Dec

REPOSITORIES: biostudies-literature

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Stiff-Person Syndrome and Graves' Disease: A Pediatric Case Report.

Medeiros Lais Moreira LM Morais Thulio Carvalho TC Primo Arlete Esteves Lopes AEL Speltri Valeria Casella VC Rocha Maria Sheila Guimaraes MSG

Child neurology open 20160101

A 9-year-old female child presented with a history of falls, weight loss, diffuse leg pain, and progressive gait disorder, following 1 previous event described as a tonic-clonic seizure. She had increased thyroid volume, brisk symmetric reflexes, abnormal gait, and painful spasms of the paraspinal musculature. Thyroid function tests indicated biochemical hyperthyroidism, and thyrotropin receptor antibodies were positive. Her electromyography showed continuous activation of normal motor units of ...[more]

PMID: 28503622

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