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Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference.

ABSTRACT: The French Intensive Care Society organized its yearly Paris International Conference in intensive care on June 18-19, 2015. The main purpose of this meeting is to gather the best experts in the field in order to provide the highest quality update on a chosen topic. In 2015, the selected theme was: "Acute Renal Failure in the ICU: from injury to recovery." The conference program covered multiple aspects of renal failure, including epidemiology, diagnosis, treatment and kidney support system, prognosis and recovery together with acute renal failure in specific settings. The present report provides a summary of every presentation including the key message and references and is structured in eight sections: (a) diagnosis and evaluation, (b) old and new diagnosis tools,

SUBMITTER: Bellomo R

PROVIDER: S-EPMC5418176 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference.

Bellomo Rinaldo R Ronco Claudio C Mehta Ravindra L RL Asfar Pierre P Boisramé-Helms Julie J Darmon Michael M Diehl Jean-Luc JL Duranteau Jacques J Hoste Eric A J EAJ Olivier Joannes-Boyau JB Legrand Matthieu M Lerolle Nicolas N Malbrain Manu L N G MLNG Mårtensson Johan J Oudemans-van Straaten Heleen M HM Parienti Jean-Jacques JJ Payen Didier D Perinel Sophie S Peters Esther E Pickkers Peter P Rondeau Eric E Schetz Miet M Vinsonneau Christophe C Wendon Julia J Zhang Ling L Laterre Pierre-François PF

Annals of intensive care 20170504 1

The French Intensive Care Society organized its yearly Paris International Conference in intensive care on June 18-19, 2015. The main purpose of this meeting is to gather the best experts in the field in order to provide the highest quality update on a chosen topic. In 2015, the selected theme was: "Acute Renal Failure in the ICU: from injury to recovery." The conference program covered multiple aspects of renal failure, including epidemiology, diagnosis, treatment and kidney support system, pro ...[more]

PMID: 28474317

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Project description:BackgroundWhile acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking.MethodsA retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1-365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021.FindingsAdvanced age (HR 2.77, 95%CI 2.53-3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03-4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55-5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14-1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37-0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17-1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20-1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45-1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80-13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10-1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32-1.67) and 365 days (RR 1.54, 95%CI 1.21-1.96) compared to COVID-19 patients with no AKI.InterpretationCOVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery.FundingAuthors are supported by various funders, with full details stated in the acknowledgement section.

Dataset Information

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference.

Publications

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference.

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