SH3 domains: modules of protein-protein interactions.
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ABSTRACT:
SUBMITTER: Kurochkina N
PROVIDER: S-EPMC5418429 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
SH3 domains: modules of protein-protein interactions.
Kurochkina Natalya N Guha Udayan U
Biophysical reviews 20120620 1
Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements i ...[more]
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