Ontology highlight
ABSTRACT:
SUBMITTER: Kristensen O
PROVIDER: S-EPMC1383563 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Kristensen Ole O Guenat Sylvie S Dar Imran I Allaman-Pillet Nathalie N Abderrahmani Amar A Ferdaoussi Mourad M Roduit Raphaël R Maurer Fabienne F Beckmann Jacques S JS Kastrup Jette S JS Gajhede Michael M Bonny Christophe C
The EMBO journal 20060202 4
Islet-brain 1 (IB1 or JIP-1) is a scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway. IB1 is expressed at high levels in neurons and in pancreatic beta-cells, where it controls expression of several insulin-secretory components and secretion. IB1 has been shown to homodimerize, but neither the molecular mechanisms nor the function of dimerization have yet been characterized. Here, we show that IB1 homodimerizes through a novel and uni ...[more]