Ontology highlight
ABSTRACT:
SUBMITTER: Hasel P
PROVIDER: S-EPMC5418577 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hasel Philip P Dando Owen O Jiwaji Zoeb Z Baxter Paul P Todd Alison C AC Heron Samuel S Márkus Nóra M NM McQueen Jamie J Hampton David W DW Torvell Megan M Tiwari Sachin S SS McKay Sean S Eraso-Pichot Abel A Zorzano Antonio A Masgrau Roser R Galea Elena E Chandran Siddharthan S Wyllie David J A DJA Simpson T Ian TI Hardingham Giles E GE
Nature communications 20170502
The influence that neurons exert on astrocytic function is poorly understood. To investigate this, we first developed a system combining cortical neurons and astrocytes from closely related species, followed by RNA-seq and in silico species separation. This approach uncovers a wide programme of neuron-induced astrocytic gene expression, involving Notch signalling, which drives and maintains astrocytic maturity and neurotransmitter uptake function, is conserved in human development, and is disrup ...[more]