Ontology highlight
ABSTRACT:
SUBMITTER: Van Damme P
PROVIDER: S-EPMC1976195 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Van Damme Philip P Bogaert Elke E Dewil Maarten M Hersmus Nicole N Kiraly Dora D Scheveneels Wendy W Bockx Ilse I Braeken Dries D Verpoorten Nathalie N Verhoeven Kristien K Timmerman Vincent V Herijgers Paul P Callewaert Geert G Carmeliet Peter P Van Den Bosch Ludo L Robberecht Wim W
Proceedings of the National Academy of Sciences of the United States of America 20070905 37
Influx of Ca(2+) ions through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors contributes to neuronal damage in stroke, epilepsy, and neurodegenerative disorders such as ALS. The Ca(2+) permeability of AMPA receptors is largely determined by the glutamate receptor 2 (GluR2) subunit, receptors lacking GluR2 being permeable to Ca(2+) ions. We identified a difference in GluR2 expression in motor neurons from two rat strains, resulting in a difference in vulnerability to AM ...[more]