Ontology highlight
ABSTRACT:
SUBMITTER: Lucchetta EM
PROVIDER: S-EPMC5419863 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Lucchetta Elena M EM Ohlstein Benjamin B
Cell stem cell 20170323 5
Organ fitness depends on appropriate maintenance of stem cell populations, and aberrations in functional stem cell numbers are associated with malignancies and aging. Symmetrical division is the best characterized mechanism of stem cell replacement, but other mechanisms could also be deployed, particularly in situations of high stress. Here, we show that after severe depletion, intestinal stem cells (ISCs) in the Drosophila midgut are replaced by spindle-independent ploidy reduction of cells in ...[more]