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Epigenome-wide association analysis revealed that SOCS3 methylation influences the effect of cumulative stress on obesity.


ABSTRACT: Chronic stress has a significant impact on obesity. However, how stress influences obesity remains unclear. We conducted an epigenome-wide DNA methylation association analysis of obesity (N=510) and examined whether cumulative stress influenced the DNA methylation on body weight. We identified 20 CpG sites associated with body mass index at the false discovery rate q<0.05, including a novel site, cg18181703, in suppressor of cytokine signaling 3 (SOCS3) gene (coefficient ?=-0.0022, FDR q=4.94×10-5). The interaction between cg18181703 and cumulative adverse life stress contributed to variations in body weight (p=0.002). Individuals with at least five major life events and lower methylation of cg1818703 showed a 1.38-fold higher risk of being obese (95%CI: 1.17-1.76). Our findings suggest that aberrant in DNA methylation is associated with body weight and that methylation of SOCS3 moderates the effect of cumulative stress on obesity.

SUBMITTER: Xu K 

PROVIDER: S-EPMC5419875 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Epigenome-wide association analysis revealed that SOCS3 methylation influences the effect of cumulative stress on obesity.

Xu Ke K   Zhang Xinyu X   Wang Zuoheng Z   Hu Ying Y   Sinha Rajita R  

Biological psychology 20161105


Chronic stress has a significant impact on obesity. However, how stress influences obesity remains unclear. We conducted an epigenome-wide DNA methylation association analysis of obesity (N=510) and examined whether cumulative stress influenced the DNA methylation on body weight. We identified 20 CpG sites associated with body mass index at the false discovery rate q<0.05, including a novel site, cg18181703, in suppressor of cytokine signaling 3 (SOCS3) gene (coefficient β=-0.0022, FDR q=4.94×10  ...[more]

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