Epigenome-wide association analysis revealed that SOCS3 methylation influences the effect of cumulative stress on obesity.
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ABSTRACT:
SUBMITTER: Xu K
PROVIDER: S-EPMC5419875 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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Epigenome-wide association analysis revealed that SOCS3 methylation influences the effect of cumulative stress on obesity.
Xu Ke K Zhang Xinyu X Wang Zuoheng Z Hu Ying Y Sinha Rajita R
Biological psychology 20161105
Chronic stress has a significant impact on obesity. However, how stress influences obesity remains unclear. We conducted an epigenome-wide DNA methylation association analysis of obesity (N=510) and examined whether cumulative stress influenced the DNA methylation on body weight. We identified 20 CpG sites associated with body mass index at the false discovery rate q<0.05, including a novel site, cg18181703, in suppressor of cytokine signaling 3 (SOCS3) gene (coefficient β=-0.0022, FDR q=4.94×10 ...[more]
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