Ontology highlight
ABSTRACT:
SUBMITTER: Kundu S
PROVIDER: S-EPMC5421375 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Kundu Sharmistha S Ji Fei F Sunwoo Hongjae H Jain Gaurav G Lee Jeannie T JT Sadreyev Ruslan I RI Dekker Job J Kingston Robert E RE
Molecular cell 20170201 3
Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during differentiation and development. Some PcG proteins covalently modify histones, which contributes to heritable repression. The role for other effects on chromatin structure is less understood. We characterized the organization of PcG target genes in ESCs and neural progenitors using 5C and super-resolution microscopy. The genomic loci of repressed PcG targets formed discrete, small (20-140 ...[more]