Ontology highlight
ABSTRACT:
SUBMITTER: Fischer GJ
PROVIDER: S-EPMC5422543 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Fischer Gregory J GJ Bacon William W Yang Jun J Palmer Jonathan M JM Dagenais Taylor T Hammock Bruce D BD Keller Nancy P NP
Frontiers in microbiology 20170509
The opportunistic human pathogen <i>Aspergillus fumigatus</i> initiates invasive growth through a programmed germination process that progresses from dormant spore to swollen spore (SS) to germling (GL) and ultimately invasive hyphal growth. We find a lipoxygenase with considerable homology to human Alox5 and Alox15, LoxB, that impacts the transitions of programmed spore germination. Overexpression of <i>loxB</i> (<i>OE::loxB</i>) increases germination with rapid advance to the GL stage. However ...[more]