Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC5605802 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zhu Shizhen S Zhang Xiaoling X Weichert-Leahey Nina N Dong Zhiwei Z Zhang Cheng C Lopez Gonzalo G Tao Ting T He Shuning S Wood Andrew C AC Oldridge Derek D Ung Choong Yong CY van Ree Janine H JH Khan Amish A Salazar Brittany M BM Lummertz da Rocha Edroaldo E Zimmerman Mark W MW Guo Feng F Cao Hong H Hou Xiaonan X Weroha S John SJ Perez-Atayde Antonio R AR Neuberg Donna S DS Meves Alexander A McNiven Mark A MA van Deursen Jan M JM Li Hu H Maris John M JM Look A Thomas AT
Cancer cell 20170831 3
A genome-wide association study identified LMO1, which encodes an LIM-domain-only transcriptional cofactor, as a neuroblastoma susceptibility gene that functions as an oncogene in high-risk neuroblastoma. Here we show that dβh promoter-mediated expression of LMO1 in zebrafish synergizes with MYCN to increase the proliferation of hyperplastic sympathoadrenal precursor cells, leading to a reduced latency and increased penetrance of neuroblastomagenesis. The transgenic expression of LMO1 also promo ...[more]