Ontology highlight
ABSTRACT:
SUBMITTER: Cordani M
PROVIDER: S-EPMC5423176 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cordani Marco M Oppici Elisa E Dando Ilaria I Butturini Elena E Dalla Pozza Elisa E Nadal-Serrano Mercedes M Oliver Jordi J Roca Pilar P Mariotto Sofia S Cellini Barbara B Blandino Giovanni G Palmieri Marta M Di Agostino Silvia S Donadelli Massimo M
Molecular oncology 20160412 7
Mutations in TP53 gene play a pivotal role in tumorigenesis and cancer development. Here, we report that gain-of-function mutant p53 proteins inhibit the autophagic pathway favoring antiapoptotic effects as well as proliferation of pancreas and breast cancer cells. We found that mutant p53 significantly counteracts the formation of autophagic vesicles and their fusion with lysosomes throughout the repression of some key autophagy-related proteins and enzymes as BECN1 (and P-BECN1), DRAM1, ATG12, ...[more]