Targeting Autophagy for Oncolytic Immunotherapy.
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ABSTRACT:
SUBMITTER: Hu L
PROVIDER: S-EPMC5423490 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Targeting Autophagy for Oncolytic Immunotherapy.
Hu Lulu L Jiang Ke K Ding Chan C Meng Songshu S
Biomedicines 20170111 1
Oncolytic viruses (OVs) are capable of exerting anti-cancer effects by a variety of mechanisms, including immune-mediated tumor cell death, highlighting their potential use in immunotherapy. Several adaptation mechanisms such as autophagy contribute to OV-mediated anti-tumor properties. Autophagy regulates immunogenic signaling during cancer therapy which can be utilized to design therapeutic combinations using approaches that either induce or block autophagy to potentiate the therapeutic effica ...[more]
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