Ontology highlight
ABSTRACT:
SUBMITTER: Alves V
PROVIDER: S-EPMC5423727 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Alves Vinicius V Muratov Eugene E Capuzzi Stephen S Politi Regina R Low Yen Y Braga Rodolpho R Zakharov Alexey V AV Sedykh Alexander A Mokshyna Elena E Farag Sherif S Andrade Carolina C Kuz'min Victor V Fourches Denis D Tropsha Alexander A
Green chemistry : an international journal and green chemistry resource : GC 20160628 16
Structural alerts are widely accepted in chemical toxicology and regulatory decision support as a simple and transparent means to flag potential chemical hazards or group compounds into categories for read-across. However, there has been a growing concern that alerts disproportionally flag too many chemicals as toxic, which questions their reliability as toxicity markers. Conversely, the rigorously developed and properly validated statistical QSAR models can accurately and reliably predict the t ...[more]