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The Influence of Mexican Hat Recurrent Connectivity on Noise Correlations and Stimulus Encoding.

ABSTRACT: Noise correlations are a common feature of neural responses and have been observed in many cortical areas across different species. These correlations can influence information processing by enhancing or diminishing the quality of the neural code, but the origin of these correlations is still a matter of controversy. In this computational study we explore the hypothesis that noise correlations are the result of local recurrent excitatory and inhibitory connections. We simulated two-dimensional networks of adaptive spiking neurons with local connection patterns following Gaussian kernels. Noise correlations decay with distance between neurons but are only observed if the range of excitatory connections is smaller than the range of inhibitory connections ("Mexican hat" connectivity) and if the connection strengths are sufficiently strong. These correlations arise from a moving blob-like structure of evoked activity, which is absent if inhibitory interactions have a smaller range ("inverse Mexican hat" connectivity). Spatially structured external inputs fixate these blobs to certain locations and thus effectively reduce noise correlations. We further investigated the influence of these network configurations on stimulus encoding. On the one hand, the observed correlations diminish information about a stimulus encoded by a network. On the other hand, correlated activity allows for more precise encoding of stimulus information if the decoder has only access to a limited amount of neurons.

SUBMITTER: Meyer R

PROVIDER: S-EPMC5423970 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:In the low stimulus environment project, we aimed to reduce the levels of intrusive background noise on an older adult mental health ward, combining a very straightforward measure on decibel levels with a downstream measure of reduced distress and agitation as expressed in incidents of violence. This project on reducing background noise levels on older adult wards stemmed from work the team had done on reducing levels of violence and aggression. We approached the problem using quality improvement methods. Reducing harm to patients and staff is a strategic aim of our Trust and in our efforts we were supported by the Trust's extensive programme of quality improvement, including training and support provided by the Institute for Healthcare Improvement and the trust's own Quality Improvement team. Prior to the project we were running a weekly multi-disciplinary quality improvement group on the ward. We established from this a sub-group to address the specific problem of noise levels and invited carers of people with dementia on our ward to the group. The project was led by nursing staff. We used a noise meter app readily downloadable from the internet to monitor background noise levels on the ward and establish a baseline measure. As a group we used a driver diagram to identify an overall aim and a clear understanding of the major factors that would drive improvements. We also used a staff and carer survey to identify further areas to work on. Change ideas that came from staff and carers included the use of the noise meter to track and report back on noise levels, the use of posters to remind staff about noise levels, the introduction of a visual indication of current noise levels (the Yacker Tracker), the addition of relaxing background music, and adaptations to furniture and environment. We tested many of these over the course of nine months in 2015, using the iterative learning gained from multiple PDSA cycles. The specific aim was a decrease from above 60dB to below 50dB in background noise on the wards. Following our interventions, we have managed to decrease noise levels on the ward to 53dB on average. The success of this project to date has relied on the involvement of ward staff and carers - those most affected by the problem - in generating workable local solutions. As many of the change ideas amounted to harm free interventions it was easier for us to make a case to test them out in the real-life setting. Nevertheless we were surprised at how effective such seemingly simple ideas have been in improving the environment on the ward. We have incorporated the change ideas into routine practice and are advising other wards on similar projects.

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The Influence of Mexican Hat Recurrent Connectivity on Noise Correlations and Stimulus Encoding.

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