Ontology highlight
ABSTRACT:
SUBMITTER: Sen P
PROVIDER: S-EPMC5424545 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Sen Payel P Luo Jie J Hada Arjan A Hailu Solomon G SG Dechassa Mekonnen Lemma ML Persinger Jim J Brahma Sandipan S Paul Somnath S Ranish Jeff J Bartholomew Blaine B
Cell reports 20170201 9
The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 subunit of SWI/SNF is a tumor suppressor frequently lost in pediatric rhabdoid cancers. We examined the effects of Snf5 loss on the composition, nucleosome binding, recruitment, and remodeling activities of yeast SWI/SNF. The Snf5 subunit is shown by crosslinking-mass spectrometry (CX-MS) and subunit deletion analysis to interact with ...[more]