Ontology highlight
ABSTRACT:
SUBMITTER: Choi J
PROVIDER: S-EPMC4343085 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Choi Jinwook J Jeon Shin S Choi Seungjin S Park Kyungsoo K Seong Rho Hyun RH
Proceedings of the National Academy of Sciences of the United States of America 20150202 7
Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is known about the role of chromatin remodeling factors for regulation of GC formation. Here, we show that the SWI/SNF chromatin remodeling complex is required for GC reactions. Mice lacking Srg3/mBaf155, a core component of the SWI/S ...[more]