The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.
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ABSTRACT:
SUBMITTER: Wagner KD
PROVIDER: S-EPMC5425123 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.
Wagner Kay-Dietrich KD Ying Yilin Y Leong Waiian W Jiang Jie J Hu Xuefei X Chen Yi Y Michiels Jean-François JF Lu Yiming Y Gilson Eric E Wagner Nicole N Ye Jing J
Aging 20170401 4
Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in Emaintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and ag ...[more]
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