Ontology highlight
ABSTRACT:
SUBMITTER: Okeyo-Owuor T
PROVIDER: S-EPMC5425180 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Okeyo-Owuor Theresa T Benesh Emily E Bibbey Scott S Reid Michaela M Halabi Jacques J Sutcliffe Siobhan S Moley Kelle K
PloS one 20170510 5
Prostate cancer research has been predominantly focused on adult exposures and risk factors. However, because the prostate develops during gestation and early life, exposure to external factors, such as obesity, during development could affect the prostate cancer progression in adults. Our previous work demonstrated that exposure to a high fat/high sugar (HF/HS) diet during gestation and until weaning stimulated prostate hyperplasia and altered the Pten/Akt pathway in adult mice fed a normal die ...[more]