Ontology highlight
ABSTRACT:
SUBMITTER: Baretic D
PROVIDER: S-EPMC5425235 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Baretić Domagoj D Pollard Hannah K HK Fisher David I DI Johnson Christopher M CM Santhanam Balaji B Truman Caroline M CM Kouba Tomas T Fersht Alan R AR Phillips Christopher C Williams Roger L RL
Science advances 20170510 5
ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase-related protein kinase (PIKK) best known for its role in DNA damage response. ATM also functions in oxidative stress response, insulin signaling, and neurogenesis. Our electron cryomicroscopy (cryo-EM) suggests that human ATM is in a dynamic equilibrium between closed and open dimers. In the closed state, the PIKK regulatory domain blocks the peptide substrate-binding site, suggesting that this conformation may represent an i ...[more]