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Application of advanced fluorescence microscopy to the structure of meiotic chromosomes.

ABSTRACT: Chromosomes undergoing meiosis are defined by a macromolecular protein assembly called the synaptonemal complex which holds homologs together and carries out important meiotic functions. By retaining the molecular specificity, multiplexing ability, and in situ imaging capabilities of fluorescence microscopy, but with vastly increased resolution, 3D-SIM and other superresolution techniques are poised to make significant discoveries about the structure and function of the synaptonemal complex. This review discusses recent developments in this field and poses questions approachable with current and future technology.

SUBMITTER: Carlton PM

PROVIDER: S-EPMC5425730 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Application of advanced fluorescence microscopy to the structure of meiotic chromosomes.

Carlton Peter M PM

Biophysical reviews 20130413 4

Chromosomes undergoing meiosis are defined by a macromolecular protein assembly called the synaptonemal complex which holds homologs together and carries out important meiotic functions. By retaining the molecular specificity, multiplexing ability, and in situ imaging capabilities of fluorescence microscopy, but with vastly increased resolution, 3D-SIM and other superresolution techniques are poised to make significant discoveries about the structure and function of the synaptonemal complex. Thi ...[more]

PMID: 28510112

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