Ontology highlight
ABSTRACT:
SUBMITTER: Wei J
PROVIDER: S-EPMC5426817 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wei Jiajie J Zanker Damien D Di Carluccio Anthony R AR Smelkinson Margery G MG Takeda Kazuyo K Seedhom Mina O MO Dersh Devin D Gibbs James S JS Yang Ning N Jadhav Ajit A Chen Weisan W Yewdell Jonathan W JW
Journal of immunology (Baltimore, Md. : 1950) 20170331 10
CD8<sup>+</sup> T cell immunosurveillance is based on recognizing oligopeptides presented by MHC class I molecules. Despite decades of study, the importance of protein ubiquitylation to peptide generation remains uncertain. In this study, we examined the ability of MLN7243, a recently described ubiquitin-activating enzyme E1 inhibitor, to block overall cytosolic peptide generation and generation of specific peptides from vaccinia- and influenza A virus-encoded proteins. We show that MLN7243 rapi ...[more]