Ontology highlight
ABSTRACT:
SUBMITTER: Gossel G
PROVIDER: S-EPMC5426903 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Gossel Graeme G Hogan Thea T Cownden Daniel D Seddon Benedict B Yates Andrew J AJ
eLife 20170310
Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to the maintenance of memory compartments. Here, we characterise the kinetics and structure of murine CD4 T cell memory subsets by measuring the rates of influx of new cells and using detailed timecourses of DNA labelling that also distinguish the behav ...[more]