Ontology highlight
ABSTRACT:
SUBMITTER: Tubo NJ
PROVIDER: S-EPMC4776317 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Tubo Noah J NJ Fife Brian T BT Pagan Antonio J AJ Kotov Dmitri I DI Goldberg Michael F MF Jenkins Marc K MK
Science (New York, N.Y.) 20160101 6272
Infection elicits CD4(+) memory T lymphocytes that participate in protective immunity. Although memory cells are the progeny of naïve T cells, it is unclear that all naïve cells from a polyclonal repertoire have memory cell potential. Using a single-cell adoptive transfer and spleen biopsy method, we found that in mice, essentially all microbe-specific naïve cells produced memory cells during infection. Different clonal memory cell populations had different B cell or macrophage helper compositio ...[more]