Ontology highlight
ABSTRACT:
SUBMITTER: Aid M
PROVIDER: S-EPMC5426912 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Aid Malika M Abbink Peter P Larocca Rafael A RA Boyd Michael M Nityanandam Ramya R Nanayakkara Ovini O Martinot Amanda J AJ Moseley Edward T ET Blass Eryn E Borducchi Erica N EN Chandrashekar Abishek A Brinkman Amanda L AL Molloy Katherine K Jetton David D Tartaglia Lawrence J LJ Liu Jinyan J Best Katharine K Perelson Alan S AS De La Barrera Rafael A RA Lewis Mark G MG Barouch Dan H DH
Cell 20170427 4
Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) and lymph nodes (LN) of infected rhesus monkeys for weeks after virus has been cleared from peripheral blood, urine, and mucosal secretions. ZIKV-specific neutralizing antibodies co ...[more]